Cancer Metabolism and Its Therapeutic Implications
نویسندگان
چکیده
منابع مشابه
The Role of PGC1a in Cancer Metabolism and its Therapeutic Implications
PGC1a is a transcription factor coactivator that influences a majority of cellular metabolic pathways. Abnormal expression of PGC1a is associated with several chronic diseases and, in recent years, it has been shown to be a critical controller of cancer development. PGC1a acts as a stress sensor in cancer cells and can be activated by nutrient deprivation, oxidative damage, and chemotherapy. It...
متن کاملThe Role of PGC1α in Cancer Metabolism and its Therapeutic Implications.
PGC1α is a transcription factor coactivator that influences a majority of cellular metabolic pathways. Abnormal expression of PGC1α is associated with several chronic diseases and, in recent years, it has been shown to be a critical controller of cancer development. PGC1α acts as a stress sensor in cancer cells and can be activated by nutrient deprivation, oxidative damage, and chemotherapy. It...
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PPARs are ligand activated transcription factors. PPARγ agonists have been reported as a new and potentially efficacious treatment of inflammation, diabetes, obesity, cancer, AD, and schizophrenia. Since cancer cells show dysregulation of glycolysis they are potentially manageable through changes in metabolic environment. Interestingly, several of the genes involved in maintaining the metabolic...
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Information on how drugs are metabolized is not only of importance in understanding their therapeutic action, but can furnish useful clues for the development of new drugs. The various aspects of drug metabolism studies which are considered in this paper are (i) Pathways of drug metabolism— conversion to active, inactive or toxic metabolites; (ii) Structural changes which determine a drug's met...
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Since the seminal work it is known that inflammation is a major risk factor for cancer. Inflammation can be caused by agents as diverse as heat, cold, foreign body or chemicals. In every case, there is a protein leak from the damaged capillaries. This results in increased oncotic pressure which is in turn responsible for the methylation of the PP2A phosphatase. The activation of PP2A results in...
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ژورنال
عنوان ژورنال: Journal of Cell Science & Therapy
سال: 2013
ISSN: 2157-7013
DOI: 10.4172/2157-7013.1000143